behavioural
epigenetics
The author, Margaret Tyson, was an honorary researcher at the Institute of Cancer Sciences, The University of Manchester and now researches epigenetics particularly of cancer and schizophrenia. She also runs Manchester Amputee Fitnesss Initiative and Karen's Page.
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
Schizophrenia Summary
Stress to schizophrenia
The previous page indicated that behaviour may alter genes through epigenetic change and may contribute to schizophrenia and psychoses.
This page summarises how stress through abnormal behaviour may lead to epigenetic changes through a cycle that may lead to schizophrenia and psychosis. Details of how this may happen are given on the following pages.
The diagram below graphically summarises a cycle that may lead to the development of schizophrenia. Each time the cycle takes place schizophrenic symptoms may worsen because of the need to top up dopamine - proposed here as possibly leading to a type of addiction. This can be demonstrated by comparing the cycle with a stress-reward loop and a generalised substance addiction cycle (see below).
Click on the diagram to access a more detailed description and references.
Diagram: Proposed behavioural mechanisms leading to epigenetically derived schizophrenia (Click on diagram for explanation and references)
Diagram: Based on Are you addicted to stress? (here's how to know) -Part 1 Dr Maryam Falahatpishe 2025
In bold the original steps proposed by Dr Maryam Falahatpishe
Diagram: Generalised substance addiction cycle (reference: Drogue: aide et référence https://www.aidedrogue.ca/en/the-addiction-cycle/#
